abstract：BACKGROUND & AIMS:Integrity of the intestinal epithelium is required for nutrition absorption and defense against pathogens. Claudins are cell adhesion molecules that localize at tight junctions (TJs); many are expressed in the intestinal tract, but little is known about their functions. Claudin-7 is unique in that it ...

journal_title：Gastroenterology

authors： Ding L,Lu Z,Foreman O,Tatum R,Lu Q,Renegar R,Cao J,Chen YH

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND & AIMS:Induction of colitis in mice by administration of oxazolone is mediated by T-helper (Th) 2 cells and has features of human ulcerative colitis. We investigated whether activation of interleukin (IL)-4Rα on T and B cells determines their effector functions and mediates oxazolone-induced colitis. METHOD...

journal_title：Gastroenterology

authors： Hoving JC,Kirstein F,Nieuwenhuizen NE,Fick LC,Hobeika E,Reth M,Brombacher F

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND & AIMS:The incidence of Barrett's esophagus and esophageal adenocarcinoma has increased despite surveillance of patients with Barrett's esophagus. Limited data indicate that nonsteroidal anti-inflammatory drug (NSAID) and statin use reduce the risk for esophageal adenocarcinoma. We investigated whether NSAID...

journal_title：Gastroenterology

authors： Kastelein F,Spaander MC,Biermann K,Steyerberg EW,Kuipers EJ,Bruno MJ,Probar-study Group.

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND & AIMS:As life expectancy increases, there are greater numbers of patients with liver diseases who require surgery or transplantation. Livers of older patients have significantly less reparative capacity following ischemia and reperfusion (I/R) injury, which occurs during these operations. There are no strat...

journal_title：Gastroenterology

authors： Wang JH,Ahn IS,Fischer TD,Byeon JI,Dunn WA Jr,Behrns KE,Leeuwenburgh C,Kim JS

更新日期：2011-12-01 00:00:00

abstract：:Inflammasomes are multi-protein complexes that mediate activation of caspase-1, which promotes secretion of the proinflammatory cytokines interleukin-1β and interleukin-18 and pyroptosis, a form of phagocyte cell death induced by bacterial pathogens. Members of the Nod-like receptor family (including Nlrp1, Nlrp3, and...

journal_title：Gastroenterology

authors： Chen GY,Núñez G

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND & AIMS:To investigate the peripheral sensory effects of repeated stress in patients with postinfectious irritable bowel syndrome (IBS), we tested whether stress following self-limiting bacterial colitis increases colonic dorsal root ganglia (DRG) nociceptive signaling. METHODS:C57BL/6 mice were infected wit...

journal_title：Gastroenterology

authors： Ibeakanma C,Ochoa-Cortes F,Miranda-Morales M,McDonald T,Spreadbury I,Cenac N,Cattaruzza F,Hurlbut D,Vanner S,Bunnett N,Vergnolle N,Vanner S

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND & AIMS:The effects of trypsin on pancreatic ductal epithelial cells (PDECs) vary among species and depend on the localization of proteinase-activated receptor 2 (PAR-2). We compared PAR-2 localization in human and guinea-pig PDECs, and used isolated guinea pig ducts to study the effects of trypsin and a PAR-...

journal_title：Gastroenterology

authors： Pallagi P,Venglovecz V,Rakonczay Z Jr,Borka K,Korompay A,Ozsvári B,Judák L,Sahin-Tóth M,Geisz A,Schnúr A,Maléth J,Takács T,Gray MA,Argent BE,Mayerle J,Lerch MM,Wittmann T,Hegyi P

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND & AIMS:Intestinal microbes induce homeostatic mucosal immune responses, but can also cause inappropriate immune activation in genetically susceptible hosts. Although immune responses to bacterial products have been studied extensively, little is known about how intestinal inflammation affects functions of co...

journal_title：Gastroenterology

authors： Patwa LG,Fan TJ,Tchaptchet S,Liu Y,Lussier YA,Sartor RB,Hansen JJ

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND & AIMS:Progressive familial intrahepatic cholestasis can be caused by mutations in ABCB4 or ATP8B1; each encodes a protein that translocates phospholipids, but in opposite directions. ABCB4 flops phosphatidylcholine from the inner to the outer leaflet, where it is extracted by bile salts. ATP8B1, in complex ...

journal_title：Gastroenterology

authors： Groen A,Romero MR,Kunne C,Hoosdally SJ,Dixon PH,Wooding C,Williamson C,Seppen J,Van den Oever K,Mok KS,Paulusma CC,Linton KJ,Oude Elferink RP

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND & AIMS:Alterations in the gastrointestinal microbiota have been associated with metabolic diseases. However, little is known about host factors that induce changes in gastrointestinal bacterial populations. We investigated the role of bile acids in this process because of their strong antimicrobial activitie...

journal_title：Gastroenterology

authors： Islam KB,Fukiya S,Hagio M,Fujii N,Ishizuka S,Ooka T,Ogura Y,Hayashi T,Yokota A

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND & AIMS:In the Active Ulcerative Colitis Trial (ACT)-1 and ACT-2, patients with ulcerative colitis treated with infliximab were more likely than those given placebo to have a clinical response, undergo remission, and have mucosal healing. We investigated the association between early improvement (based on end...

journal_title：Gastroenterology

authors： Colombel JF,Rutgeerts P,Reinisch W,Esser D,Wang Y,Lang Y,Marano CW,Strauss R,Oddens BJ,Feagan BG,Hanauer SB,Lichtenstein GR,Present D,Sands BE,Sandborn WJ

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND & AIMS:Mathematical modeling of hepatitis C virus (HCV) kinetics indicated that cellular immune responses contribute to interferon (IFN)-induced clearance of HCV. We investigated a potential role of natural killer (NK) cells in this process. METHODS:Phenotype and function of blood and liver NK cells were st...

journal_title：Gastroenterology

authors： Ahlenstiel G,Edlich B,Hogdal LJ,Rotman Y,Noureddin M,Feld JJ,Holz LE,Titerence RH,Liang TJ,Rehermann B

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND & AIMS:Cirrhotic liver diseases are associated with abnormalities in cardiac geometry and function in adults (cirrhotic cardiomyopathy) but rarely explored in cirrhotic infants or children. We proposed that features of cirrhotic cardiomyopathy are present in infants with cirrhosis due to biliary atresia (BA)...

journal_title：Gastroenterology

authors： Desai MS,Zainuer S,Kennedy C,Kearney D,Goss J,Karpen SJ

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND & AIMS:There have been conflicting results on a cell of origin in pancreatic regeneration. These discrepancies predominantly stem from lack of specific markers for the pancreatic precursors/stem cells, as well as differences in the targeted cells and severity of tissue injury in the experimental models so fa...

journal_title：Gastroenterology

authors： Criscimanna A,Speicher JA,Houshmand G,Shiota C,Prasadan K,Ji B,Logsdon CD,Gittes GK,Esni F

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND & AIMS:Patients with inflammatory bowel disease who are in remission and those who developed irritable bowel syndrome after enteric infection continue to have symptoms of diarrhea or constipation in the absence of overt inflammation, indicating motility dysfunction. We investigated whether oxidative stress d...

journal_title：Gastroenterology

authors： Choi K,Chen J,Mitra S,Sarna SK

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND & AIMS:Improving methods for early detection of gastric cancer could reduce mortality. Measurements of serum pepsinogen levels have been used for screening in Japan without satisfactory levels of sensitivity or specificity. Trefoil factor family (TFF) proteins (TFF1, TFF2, and TFF3) are small and stable mole...

journal_title：Gastroenterology

authors： Aikou S,Ohmoto Y,Gunji T,Matsuhashi N,Ohtsu H,Miura H,Kubota K,Yamagata Y,Seto Y,Nakajima A,Goldenring JR,Kaminishi M,Nomura S

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND & AIMS:Pancreatic acinar cells are used to study regulated exocytosis. We investigated the role of interferon regulatory factor-2 (IRF2) in exocytosis in pancreatic acinar cells. METHODS:Pancreas tissues from Irf2⁺/⁺, Irf2⁺/⁻), and Irf2⁻/⁻ mice were examined by microscopy, immunohistochemical, and immunoblo...

journal_title：Gastroenterology

authors： Mashima H,Sato T,Horie Y,Nakagawa Y,Kojima I,Ohteki T,Ohnishi H

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND & AIMS:Ischemia and reperfusion injury are common causes of oxidative tissue damage associated with many liver diseases and hepatic surgery. The Wnt-β-catenin signaling pathway is an important regulator of hepatic development, regeneration, and carcinogenesis. However, the role of Wnt signaling in the hepato...

journal_title：Gastroenterology

authors： Lehwald N,Tao GZ,Jang KY,Sorkin M,Knoefel WT,Sylvester KG

更新日期：2011-08-01 00:00:00

abstract：:One of the least anticipated and less heralded outcomes of mouse genetics has been to rediscover whole organism physiology. Among the many unexpected findings that it has brought to our attention has been the realization that gut-derived serotonin is a hormone-inhibiting bone formation. The importance of this discover...

journal_title：Gastroenterology

authors： Karsenty G,Gershon MD

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND & AIMS:Abnormal processing of visceral sensation at the level of the central nervous system is believed to be involved in functional dyspepsia. However, compared with studies of stimulation-related changes in brain activity, few studies have focused on resting brain activity, which also is important in patho...

journal_title：Gastroenterology

authors： Zeng F,Qin W,Liang F,Liu J,Tang Y,Liu X,Yuan K,Yu S,Song W,Liu M,Lan L,Gao X,Liu Y,Tian J

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND & AIMS:Interactions between genetic and environmental factors are believed to be involved in onset and initiation of inflammatory bowel disease. We analyzed the interaction between gastrointestinal mucosal microbiota and host genes in twin pairs discordant for ulcerative colitis (UC) to study the functional ...

journal_title：Gastroenterology

authors： Lepage P,Häsler R,Spehlmann ME,Rehman A,Zvirbliene A,Begun A,Ott S,Kupcinskas L,Doré J,Raedler A,Schreiber S

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND & AIMS:In patients with chronic hepatitis C who failed to respond to standard therapy, high-dose pegylated interferon (IFN)-α and/or ribavirin could induce a stronger antiviral response and prevent treatment failure and HCV resistance when combined with direct-acting antivirals. The influence of genetic dete...

journal_title：Gastroenterology

authors： Chevaliez S,Hézode C,Soulier A,Costes B,Bouvier-Alias M,Rouanet S,Foucher J,Bronowicki JP,Tran A,Rosa I,Mathurin P,Alric L,Leroy V,Couzigou P,Mallat A,Charaf-Eddine M,Babany G,Pawlotsky JM

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND & AIMS:Dkk1 is a secreted antagonist of the Wnt/β-catenin signaling pathway. It is induced by inflammatory cytokines during colitis and exacerbates tissue damage by promoting apoptosis of epithelial cells. However, little is known about the physiologic role of Dkk1 in normal intestinal homeostasis and during...

journal_title：Gastroenterology

authors： Koch S,Nava P,Addis C,Kim W,Denning TL,Li L,Parkos CA,Nusrat A

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND & AIMS:High-level coffee consumption has been associated with reduced progression of pre-existing liver diseases and lower risk of hepatocellular carcinoma. However, its relationship with therapy for hepatitis C virus infection has not been evaluated. METHODS:Patients (n=885) from the lead-in phase of the H...

journal_title：Gastroenterology

authors： Freedman ND,Curto TM,Lindsay KL,Wright EC,Sinha R,Everhart JE,HALT-C TRIAL GROUP.

更新日期：2011-06-01 00:00:00

abstract：:Autophagy is a lysosomal pathway that degrades and recycles intracellular organelles and proteins to maintain energy homeostasis during times of nutrient deprivation and to remove damaged cell components. Recent studies have identified new functions for autophagy under basal and stressed conditions. In the liver and p...

journal_title：Gastroenterology

authors： Czaja MJ

更新日期：2011-06-01 00:00:00

abstract：:Polycystic liver diseases (PLD) are inherited disorders of the biliary epithelium, caused by genetic defects in proteins associated with intracellular organelles, mainly the endoplasmic reticulum and the cilium. PLD are characterized by the formation and progressive enlargement of multiple cysts scattered throughout t...

journal_title：Gastroenterology

authors： Strazzabosco M,Somlo S

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND & AIMS:The long-term outcomes of patients treated for autoimmune hepatitis (AIH) are considered to be good. However, follow-up data beyond 10 years are limited and confined to tertiary referral centers. We assessed long-term outcomes and determinants of outcome in patients with AIH from a nontransplant cente...

journal_title：Gastroenterology

authors： Hoeroldt B,McFarlane E,Dube A,Basumani P,Karajeh M,Campbell MJ,Gleeson D

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND & AIMS:Several studies have reported that low doses of interferon can delay the development of hepatocellular carcinoma (HCC) and progression of chronic hepatitis C. We investigated the incidence of clinical events among participants of the Evaluation of PegIntron in Control of Hepatitis C Cirrhosis (EPIC)3 ...

journal_title：Gastroenterology

authors： Bruix J,Poynard T,Colombo M,Schiff E,Burak K,Heathcote EJ,Berg T,Poo JL,Mello CB,Guenther R,Niederau C,Terg R,Bedossa P,Boparai N,Griffel LH,Burroughs M,Brass CA,Albrecht JK,EPIC3 Study Group.

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND & AIMS:The ubiquitous cross-linking enzyme tissue transglutaminase (TG2) has been implicated in irreversible collagen stabilization in liver fibrosis, although functional evidence is lacking. We studied the contribution of TG2 to hepatic fibrotic matrix stability, as well as liver fibrosis progression and re...

journal_title：Gastroenterology

authors： Popov Y,Sverdlov DY,Sharma AK,Bhaskar KR,Li S,Freitag TL,Lee J,Dieterich W,Melino G,Schuppan D

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND & AIMS:Patients with irritable bowel syndrome with diarrhea (IBS-D) have increased mucosal serotonin (5-hydroxytryptamine [5-HT]) availability, possibly because immune activation reduces activity of the 5-HT transporter (SERT). We investigated the relationship between mucosal and platelet SERT and immune act...

journal_title：Gastroenterology

authors： Foley S,Garsed K,Singh G,Duroudier NP,Swan C,Hall IP,Zaitoun A,Bennett A,Marsden C,Holmes G,Walls A,Spiller RC

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND & AIMS:Hepatitis E virus (HEV) infection can cause chronic hepatitis in recipients of solid organ transplants. However, the factors that contribute to chronic infection and the outcomes of these patients are incompletely understood. We performed a retrospective analysis of data from 17 centers from Europe an...

journal_title：Gastroenterology

authors： Kamar N,Garrouste C,Haagsma EB,Garrigue V,Pischke S,Chauvet C,Dumortier J,Cannesson A,Cassuto-Viguier E,Thervet E,Conti F,Lebray P,Dalton HR,Santella R,Kanaan N,Essig M,Mousson C,Radenne S,Roque-Afonso AM,Izopet J,

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND & AIMS:Nonsteroidal anti-inflammatory drugs (NSAIDs), including aspirin, have been implicated in diverticular complications. We examined the influence of aspirin and NSAID use on risk of diverticulitis and diverticular bleeding in a large prospective cohort. METHODS:We studied 47,210 US men in the Health Pr...

journal_title：Gastroenterology

authors： Strate LL,Liu YL,Huang ES,Giovannucci EL,Chan AT

更新日期：2011-05-01 00:00:00

abstract：:Increasing evidence has emerged that supports an important intersection between 3 fundamental cell biologic pathways in the pathogenesis of inflammatory bowel disease. These include the intersection between autophagy, as revealed by the original identification of ATG16L1 and IRGM as major genetic risk factors for Croh...

journal_title：Gastroenterology

authors： Kaser A,Blumberg RS

更新日期：2011-05-01 00:00:00

abstract：:In this review, we speculate about future therapeutic approaches for inflammatory bowel diseases (IBDs), focusing on the need for better preclinical and clinical models and approaches beyond small molecules and systemically administered biologics. We offer ideas to change clinical trial programs and to use immunologic...

journal_title：Gastroenterology

authors： Plevy SE,Targan SR

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND & AIMS:Studies of hepatitis C virus (HCV) infection, immunopathogenesis, and resulting liver diseases have been hampered by the lack of a small animal model. We developed humanized mice with human immune system and liver tissues to improve the studies of hepatitis C virus pathogenesis and treatment. METHODS...

journal_title：Gastroenterology

authors： Washburn ML,Bility MT,Zhang L,Kovalev GI,Buntzman A,Frelinger JA,Barry W,Ploss A,Rice CM,Su L

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND & AIMS:Ferroportin disease is characterized by iron overload. It has an autosomal-dominant pattern of inheritance and has been associated with mutations in the SLC40A1 gene, which encodes the cellular iron exporter ferroportin. Since the first description in 2001, about 30 mutations have been reported; the h...

journal_title：Gastroenterology

authors： Le Lan C,Mosser A,Ropert M,Detivaud L,Loustaud-Ratti V,Vital-Durand D,Roget L,Bardou-Jacquet E,Turlin B,David V,Loréal O,Deugnier Y,Brissot P,Jouanolle AM

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND & AIMS:The host immune response during the chronic phase of hepatitis C virus infection varies among individuals; some patients have a no interferon (IFN) response in the liver, whereas others have full activation of IFN-stimulated genes (ISGs). Preactivation of this endogenous IFN system is associated with ...

journal_title：Gastroenterology

authors： Dill MT,Duong FH,Vogt JE,Bibert S,Bochud PY,Terracciano L,Papassotiropoulos A,Roth V,Heim MH

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND & AIMS:We performed a prospective, randomized, controlled study to compare the combination of esomeprazole and clopidogrel vs clopidogrel alone in preventing recurrent peptic ulcers in patients with atherosclerosis and a history of peptic ulcers. We also investigated the effects of esomeprazole on the antipl...

journal_title：Gastroenterology

authors： Hsu PI,Lai KH,Liu CP

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND & AIMS:Mutations in TP53, a tumor suppressor gene, are associated with prognosis of many cancers. However, the prognostic values of TP53 mutation sites are not known for patients with hepatocellular carcinoma (HCC) because of heterogeneity in their geographic and etiologic backgrounds. METHODS:TP53 mutation...

journal_title：Gastroenterology

authors： Woo HG,Wang XW,Budhu A,Kim YH,Kwon SM,Tang ZY,Sun Z,Harris CC,Thorgeirsson SS

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND & AIMS:De novo lipogenesis is believed to be involved in oncogenesis. We investigated the role of aberrant lipid biosynthesis in the pathogenesis of human hepatocellular carcinoma (HCC). METHODS:We evaluated expression of enzymes that regulate lipogenesis in human normal liver tissues and HCC and surroundin...

journal_title：Gastroenterology

authors： Calvisi DF,Wang C,Ho C,Ladu S,Lee SA,Mattu S,Destefanis G,Delogu S,Zimmermann A,Ericsson J,Brozzetti S,Staniscia T,Chen X,Dombrowski F,Evert M

更新日期：2011-03-01 00:00:00